PharmaPLANT, A NEW POSSIBILITY TO COMBAT YIELD LOSSED CAUSED BY PLANT ASSOCIATED MICROBES

The invention relates to microbicidal preparations containing optimised mixture of furazolidon and a benzidimidazole derivative for controlling plant pathogenic fungi (stone fruit canker, Fusarium blight) and bacteria (fire blight, Erwinia black foot, citrus canker, blight of rice) even being tolerant to commercial pesticides, as well as in protection of various products to deteriorative action of microbes. The special advantages are the high variation of the composition of new active molecules via introduction of selected pharmacophores or molecules carrying the desired physicochemical properties resulting optimisation of toxicological and physico-chemical properties requests for the field of application.

The pesticidal preparation PHARMAPLANT expresses excellent protective activity applied before or after the enlightenment of the target pest. It is well tolerated by plants in therapeutic doses. Being tolerant to ambiental conditions, posses low mobility, so it expresses long term protective and curative effects.

The most important sides:

As the fate of components of PHARMAPLANT in biological medium is well known, being based on the present status of knowledge related to their metabolism as well as genetic effects there are not expected toxicological data on this new preparation dramatically different from those of its components.

i) PHARMAPLANT 40 fw is an excellent synergiser of the range of marketed fungicides. The significant shift in activity of mixtures containing PHARMAPLANT 40 fw makes possible weighty decrease in applied doses leading to reduction the time of tolerance.

ii) The efficacy of the above combinations surpasses the activity of benomyl against Botrytis and powdery mildews as well as they exert inhibitory effect against phytopathogenic bacteria on the level of streptomycin.

iii) The optimised mixtures efficiently inhibit streptomycin tolerant bacteria, the probability (f) of the appearance of strains with acquired resistance is low (f < 10^-9).

Application: - Preventively in early stage of vegetation (fruit trees) of in the time of flowering (corn).

Uses - Against leaf and bark diseases of trees (apple and stone fruits, citrus) caused by bacteria (Erwinia, Xanthomonas) and fungi (Diplodia, Cytospora, Nectria), overwintering form of apple powdery mildew, primary infections of apple scab, postharvest treatment of fruits and vegetables (citrus, beets, potato, onion, tulip) to control storage diseases.

General Dose: 0.5-1.2 kg per ha or 2-5 g per tree or 30-100 g/hl suspension.

Side effects: does not cause side effect even after 3-5 fold overdoses.

Toleranace period: 3 days

Incompatibility: not known

The PHARMAPLANT 40 fw in tankmixtures significantly impoveres the activity of microbicides of diverse mode of action (azoles, phenylamides, benzimidazoles, nitroderivatives and antibiotics). More than 40 synergetic partners were found.